Not just health hazards, but legal hazards, too. Get a DUI, and you instantly becomes a pariah to everyone around you, including work, who may fire you. Then there are the costs, fines, possible prison, increased insurance, etc.

Going out and partying it up in a city that requires cars, is too much of a risk, and getting drunk at home is kind of pathetic.

Also, legal/ semi-legal weed.