Oh fuck off. You know damn well that 90% of society would raise an eyebrow at a 3 year old boy trudging around in high heels and getting into mom’s lipstick.

NO ONE TOLD HER SHE WAS TRANS. SHE SAID THAT.

What part of this was self-determined is hard for you to understand? Transition was 100% initiated and driven BY HER. It’s what she wanted because it’s what she understood herself to be inside her own mind.

Final Destination, Expanse style? That sounds… unpleasant lol

Huh, now that’s super interesting.

Ok you and I both have to go to sleep, but now you’ve got me wondering about the eternal debate amongst our medical residents about benzos vs. barbiturates for acute alcohol withdrawal. I’ll have to read up on this some more

Bathroom? Going out Elvis style

Nice username, fam! I’ve not found an Expanse community around here yet, but I see lots of fans

Oh you’re getting in the weeds now hahaha. Looks like it’s primarily GABA_A

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326685/

I just had to look that shit up haha. I’ve never thought to check into it beyond just “you’re not breathing, so I’m about to make you very angry by reversing your high, sorry bro” lol

So, it’s interesting, because it’s well-known to have effects on the same GABA receptors as benzodiazepines (like Xanax), but none of the addictive, physical dependence problems, and apigenin doesn’t respond consistently to the drug we use to reverse benzos (called flumazenil).

So… we’re not entirely sure? It could still be the GABA effects that help with sleep. But there’s also a host of antiinflammatory neurological effects that probably better explain its efficacy against Alzheimer’s, for example.

Now, if you really want to put yourself to sleep, feel free to crawl through this alphabet soup of a research article lol:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472148/

Here, I found a good article for you:

https://www.uspharmacist.com/article/assisting-seniors-with-insomnia-a-comprehensive-approach

Literally the only thing that gives me refreshing sleep. (See also: mitochondrial dysfunction that I mentioned in my other comment about CQ10.) Apigenin seems to improve what’s called “sleep architecture” in a way that none of the pharmaceuticals I’ve ever tried do.

Yeah, long QT syndrome is estimated around 1/2000 people. Relatively rare. I fully confess that I’m just traumatized by my personal experiences with patients taking the drug lol

Hahaha, I love working with older folks. They’re my favorite patients.

I actually WOULD recommend this for seniors. It does not have any anticholinergic side effects like a lot of pharmaceutical sedatives do, and it doesn’t interact with the most common blood pressure or cardiac meds that older folks often take.

I have the same problem with magnesium supplements. Mag glycinate has less of that laxative effect than mag citrate, so she could try that as well.

The only two caveats I would add are: she should definitely tell her doctors she’s taking it, as with any OTC supplement. And if she’s specifically on a drug called warfarin (Coumadin), she should be very cautious. (Even Tylenol can cause warfarin to build up in the body. Warfarin sucks, so we don’t use it as much anymore, but it’s not unheard of.)

Hope that helps! (I’m a cardiac nurse. I work with older folks a lot.)

Yep, that’s the usual recommended dose - 200mg like an hour before bedtime

Yeah, medically cyclic vomiting syndrome is usually more associated with cannabis abuse disorder, so you’re probably not going to get far trying to get that diagnosis specifically. But that doesn’t mean these same treatment regimens won’t help. Think of it as physical therapy for the gut and nervous system.

Oh man, you are really challenging my senior citizen brain here. I think I know how to bold things haha

I like Nootropics Depot as a source company. They sell it for $20 for a 30 count bottle of 200mg capsules.

I knew this child from BIRTH. She’s the same age as my younger sister and they were very good friends growing up. From the instant this kid could express preferences - I’m talking 18 months-2 years old - we knew something was up because here’s this little boy who wants to wear dresses, play with dolls, and sneaks into mom’s high heels and makeup at home.

We just assumed she was a gay boy because none of us had ever even heard of a transgender person 30-35 years ago. Believe me, everyone discouraged this. The constant battle finally met a stalemate agreement to just keep it at home. Even then, this kid was irrepressible, hence the glittery purple scarf at school.

When she told us in high school that she was really a girl, it was the most face-palmingly obvious thing, like of course that’s what we’ve been seeing your entire life. That makes so much sense.

SHE initiated that conversation. No one EVER pushed her to do anything. She was a very active participant in her own medical decisions, which is medically appropriate for a teenager. (I’m a nurse. Teenagers should participate in their own medical decisions.)

She started puberty blockers, started living openly as a girl in RURAL OHIO 30 YEARS AGO and it was not a big fucking deal until you assholes suddenly decided it was a few years ago. She didn’t receive any permanent medical treatment for transition until she was 18.

Believe me, son, she’s PERFECTLY INTACT, happier than you, and you can fuck the fuck right off with that horse shit terminology.

It’s really safe even in absolutely large doses. (There are studies performed using doses in the multiple GRAM range.) I highly recommend trying it. Personally I take 400mg/night, which is twice the dosage you’ll see advertised. I only mention because I think the standard advertised range is probably too low for people like me.

Coenzyme Q10

Energy, mitochondrial support, antioxidant

Personally, I think everyone should be taking this. Extremely safe, improves cardiac outcomes, some evidence that it can reverse damage in chronic kidney disease. Most people won’t feel different, but I take high dose CoQ10 for mitochondrial dysfunction, and I can tell you it definitely has a huge impact. Love this stuff.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092430/

https://www.mdpi.com/2076-3921/8/2/44#:~:text=Chronic Kidney Disease (CKD),-The role of&text=There is evidence that CoQ10,dialysis in patients with CKD.

Apigenin (herbal supplement)

Insomnia, anxiety

Derived from chamomile flowers (and other plant sources), I’ve found this to be more successful in treating my chronic insomnia than any of the pharmaceutical options. (And believe me, I’ve tried them all.)

I am so sorry that she’s dealing with this. I’ve heard of successful treatment of intractable nausea using biofeedback therapy. The idea being that the body gets stuck in a negative feedback loop and trying to reverse that back to previous functioning.

https://www.researchgate.net/publication/314851129_Biofeedback_and_visualization_to_control_nausea_and_vomiting

https://pubmed.ncbi.nlm.nih.gov/21154016/#:~:text=Treatment outcome suggests that vomiting,bodily control and self-efficacy.

I hope this gets better for her.