Getting Over It - the controls themselves are your enemy. A different take on the same concept: Octodad / Manual Samuel.
One game series that is not known for being especially humorous actually can be: The Halo games. More specifically the enemy grunts. If you sneak up on them and listen to their dialogue, their mix of faux bravado, cowardice and delusion of grandeur can be really funny. Especially because Master Chief is “The Demon” to them. A near-mythical monster. Just choosing the right time to reveal your presence to the grunts can result in comedy gold.
I’m waiting for the book version of this video.
Thanks for the heads-up on this. I was entirely oblivious to the existence of custom content.